David Hymel

David Hymel

Company: Novo Nordisk

Job title: Principal Research Scientist


Photochemically-Enabled, Post-Translational Production of Therapeutic C-Terminal Amides” 2:30 pm

We have developed chemistry to convert recombinantly expressed peptides containing a C-terminal cysteine extension to a therapeutically relevant C-terminal amide via photochemical decomposition of the corresponding arylated cysteine thiol The process is robust, high-yielding, amenable to UV- or visible-light conditions, and is broadly applicable to all natural amino acid side chains at the C-terminus. We…Read more

day: Conference Day 2

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