WuXi AppTec’s DEL Technology for DIscovering Peptides with Improved Stability & Cell Permeability

Time: 10:00 am
day: Conference Day 1


  • Peptide therapeutics are emerging as viable treatments for traditionally difficult-to-drug targets, though discovery methods like phage and mRNA display face limitations such as low stability and poor cell penetration.
  • WuXi AppTec's DEL technology overcomes these issues by enabling the integration of unnatural amino acids into vast peptide libraries, thereby improving their stability and cell permeability.
  • DEL-derived libraries have produced cyclic peptides with strong inhibitory effects on the MDM2−p53 interaction, leading to valuable insights for enhancing drug properties.
  • The technology has also identified PCSK9 binding peptides, offering a promising route for novel cholesterol-lowering drugs, and tumor-specific ligands for targeted drug delivery applications.