RapaGlues – A Bridge between Macrocyclic Peptides and Molecular Glues for Interrogating Hard to Drug Targets
Time: 1:30 pm
day: Conference Day 1
Details:
- Our construction of DEL and array libraries of molecular glues will be discussed as well as our perspectives on accessing topological diversity.
- Screening of the platform has yielded chemical starting points have been discovered for several target classes. One program will described SAR leading to potent, cell permeable macrocycles for the inhibition of an oncology target.
- Our platform has yielded a development candidate for the prevention of acute kidney injury. The biological rationale and characterization of this candidate will be shown, both in vitro and in vivo efficacy data.
