PepTalk – Deep-Dive Audience Discussion Take a seat in one of the discussion sessions below and immerse yourself into an engaging discussion with thought-leading peptide pharma experts and your peers.
Practical Approaches to Characterize ADME & Design Translatable In Vitro & In Vivo PK/PD Studies with Jianzhong Wen
- What in vitro stability assays do you rely on early to triage candidates, and which have predicted in vivo best for your programs?
- Which permeability assays or systems have been most predictive for peptides in your experience?
- How much is needed to evaluate metabolism or transporter related DDI for peptide drugs?
Improving Permeating Agent Performance to Achieve Successful Peptide Oral Bioavailability with Shelley Allen
- How to use non-naturals to improve stability against proteases and other micro-environment challenges?
- How can we use half-life extension lipidation for permeating agents to improve bioavailability?
- What tissue properties or targets are important to consider for improved bioavailability?