Jianzhong Wen
Senior Principal Scientist & Group Lead Merck & Co
Wen Jianzhong has years of experience in antibody, peptide, and ADC discovery, with a focus on bioanalysis and on elucidating DMPK and PK/PD relationships in the preclinical space and in human translation.
Seminars
Thursday 30th April 2026
PepTalk – Deep-Dive Audience Discussion Take a seat in one of the discussion sessions below and immerse yourself into an engaging discussion with thought-leading peptide pharma experts and your peers.
2:30 pm
Practical Approaches to Characterize ADME & Design Translatable In Vitro & In Vivo PK/PD Studies with Jianzhong Wen
- What in vitro stability assays do you rely on early to triage candidates, and which have predicted in vivo best for your programs?
- Which permeability assays or systems have been most predictive for peptides in your experience?
- How much is needed to evaluate metabolism or transporter related DDI for peptide drugs?
Improving Permeating Agent Performance to Achieve Successful Peptide Oral Bioavailability with Shelley Allen
- How to use non-naturals to improve stability against proteases and other micro-environment challenges?
- How can we use half-life extension lipidation for permeating agents to improve bioavailability?
- What tissue properties or targets are important to consider for improved bioavailability?
Thursday 30th April 2026
Developing a Fit for Purpose Bioanalytical Strategy to Analyze a Cell-Penetrating Peptide: From Protein Precipitation to Solid Phase Extraction to Affinity Capture
1:00 pm
- Introducing the properties of cell penetrating peptides
- Discussing the challenges of bioanalysis
- Utilizing a fit for purpose bioanalytical strategy: from protein precipitation to solid phase extraction to affinity capture
