Jianzhong Wen
Senior Principal Scientist Merck & Co
Wen Jianzhong has years of experience in antibody, peptide, and ADC discovery, with a focus on bioanalysis and on elucidating DMPK and PK/PD relationships in the preclinical space and in human translation.
Seminars
Thursday 30th April 2026
Roundtable Discussion: From Discovery to Translation; Developing Cell Permeable & Orally Bioavailable Peptides with Optimal Pharmacology & DMPK
2:30 pm
- Modifying amino acids to optimise target selectivity and cell membrane permeability to achieve the right pharmacology
- Modelling protein-protein interactions in the discovery to translate into the preclinical setting
- Analysing the pharmacokinetic and biodistribution properties of highly soluble orally bioavailable peptides to ensure efficacy when entering the clinic
Thursday 30th April 2026
Developing a Fit for Purpose Bioanalytical Strategy to Analyze a Cell-Penetrating Peptide: From Protein Precipitation to Solid Phase Extraction to Affinity Capture
1:00 pm
- Introducing the properties of cell penetrating peptides
- Discussing the challenges of bioanalysis
- Utilizing a fit for purpose bioanalytical strategy: from protein precipitation to solid phase extraction to affinity capture
