Discovery & Optimization of High-Affinity Macrocyclic Peptides for PET Imaging of Human Granzyme-B
Time: 4:30 pm
day: Conference Day Two
Details:
- Reviewing modality selection and the application of mRNA display screening to identify two high affinity hit classes of granzyme B binders
- Characterizing lead candidates in a mouse xeno-graft versus host disease model and rhesus monkey distribution studies
- Discussing prioritization, affinity optimization for a single hit class and identification of a preclinical candidate
