Defining a Set of Guided Peptide Design Principles by Working Backwards Through Successful or Promising Peptide Medicinal Chemistry Campaigns
Time: 1:15 pm
day: Pre-Conference Workshop Day
Details:
Small molecules have offered both therapeutic advantages and disadvantages by obeying the bRo5. However, exploring the bRo5 space has gained popularity in recent years, with macrocycles being touted as the next drug modality set to disrupt both the drug development and healthcare space, with their unique physiochemical properties. As the preclinical potential of peptide-based therapies becomes more of a clinical reality, optimizing novel peptides to confer PPI targeting, good membrane permeability and oral bioavailability is key to propelling these drugs into the clinic and to patients in need.
This workshop provides a deep dive opportunity to learn about:
- Reviewing recent peptide drug clinical success stories, to define the target product profile (TPP) of trailblazing candidates that are being translated into the clinic and beyond
- Deciphering the commonalities of successful peptide medicinal chemistry campaigns
- Extrapolating a more refined and updated roadmap of bRo5 physicochemical properties to provide a better picture of guided peptide drug design principles
- Understanding solubility/permeability balance, CNS penetration and metabolic stability to derisk your drug development efforts
