Sam Hong
Senior Director & Head of Platform Sciences Rapafusyn Pharmaceuticals
Dr. Sam Hong is the Senior Director and Head of Platform Sciences at Rapafusyn Pharmaceuticals, where he has been pivotal in developing the company’s platform since joining as the first employee. In this role, he oversees arrayed and DNA encoded library technologies, data sciences, and automation. His leadership and technical expertise have been instrumental in Rapafusyn’s progress from inception of the company.
Seminars
Thursday 30th April 2026
Non-Degradative Macrocyclic Molecular Glue DELs
1:00 pm
- RapaGlues are non-degrading molecular glues that recruit FKBP12 to form a new PPI ternary complex, successfully
- addressing the large portion of the undrugged cytosolic and transmembrane proteome
- Leveraging the RapaGlue Platform’s proprietary DELs (over 8 billion compounds) and AI/ML-powered predictions for modelling-guided design to explore the topological diversity required to expand the range of targets
- RapaGlues promote the intracellular assembly of a proteinsized (+12kD) inhibitor, achieving a high success rate against multiple hard-to-drug targets with high potency, selectivity, and cell permeability
NEW DATA
