Sam Hong
Senior Director & Head of Platform Sciences Rapafusyn Pharmaceuticals
Seminars
Thursday 30th April 2026
Non-Degradative Macrocyclic Molecular Glue DELs
1:00 pm
- RapaGlues are non-degrading molecular glues that recruit FKBP12 to form a new PPI ternary complex, successfully
- addressing the large portion of the undrugged cytosolic and transmembrane proteome
- Leveraging the RapaGlue Platform’s proprietary DELs (over 8 billion compounds) and AI/ML-powered predictions for modelling-guided design to explore the topological diversity required to expand the range of targets
- RapaGlues promote the intracellular assembly of a proteinsized (+12kD) inhibitor, achieving a high success rate against multiple hard-to-drug targets with high potency, selectivity, and cell permeability
NEW DATA
