Christopher J Brown

Christopher J. Brown is a Principal Investigator at the Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), co-leading the P2ERL (Protein and Peptide Engineering and Research Lab).

Over the last 20 years, Christopher has carried out his research in Singapore and has had a keen interest in understanding the parameters that underpin macrocyclic peptide cell permeability. An important focus of his current work is to develop libraries to discover new binding sites using phenotypic and in vitro screens to nucleate the development of tools for target site validation and hit discovery. For example, discovering novel helical peptide interaction sites that can take advantage of the known ‘rules’ for stapled peptide development, which elicit desirable phenotypic effects.

Christopher’s research has been highly collaborative, leading to many beneficial interactions and collaboration with other A*STAR research entities (Bioinformatics Institute (BII), Institute of Sustainability for Chemicals, Energy and Environment (ISCE²)) and with external partners (MSD, IPSEN).

Christopher graduated from the University of Leeds (UK) and obtained an MRes from the University of York (UK). He then carried out his Ph.D. studies in the Structural Biochemistry group at the University of Edinburgh (UK) with Professor Malcolm Walkinshaw, before leaving for Singapore to carry out his early postdoctoral studies with Sir David Lane at the p53Lab in IMCB, where he then progressed to Principal Investigator in the p53lab, prior to his current role.