Oral Macrocyclic Peptide Inhibitors of Cytokine Signaling

• Macrocyclic peptides derived from display-based technologies occupy the intermediate chemical space between small molecules and antibodies
• Chemical matter optimization strategies using structure-guided designs and non-canonical amino acids deliver drug-like leads
• Antibody-like biological activity can be achieved in blocking cytokine signaling implicated in immune-mediated diseases

Speakers:

Kaustav Biswas

Senior Principal Scientist, Boston Discovery Chemistry

Merck & Co