• RapaGlues are non-degrading molecular glues that recruit FKBP12 to form a new PPI ternary complex, successfully
• addressing the large portion of the undrugged cytosolic and transmembrane proteome
• Leveraging the RapaGlue Platform’s proprietary DELs (over 8 billion compounds) and AI/ML-powered predictions for modelling-guided design to explore the topological diversity required to expand the range of targets
• RapaGlues promote the intracellular assembly of a proteinsized (+12kD) inhibitor, achieving a high success rate against multiple hard-to-drug targets with high potency, selectivity, and cell permeability

NEW DATA